Tuesday, November 24, 2009

Tuesday November 24, 2009
Classic vs Delayed TRALI syndrome


Characteristics of the “classic TRALI syndrome” are:
  • time of onset within 2 hours (usually up to 6 hours);
  • rapid development;
  • no other risk factors for ALI except transfusion;
  • anti-neutrophil antibodies pathophysiology and
  • onset after a single unit of blood product.

Characteristics of the “delayed TRALI syndrome” are:

  • time of onset 6-72 hours after transfusion;
  • slow development of clinical presentation;
  • patients have other risk factors for ALI (i.e. sepsis, aspiration, near-drowning, disseminated intravascular coagulation, trauma, pneumonia, drug overdose, fracture, burns and cardiopulmonary bypass);
  • two- step pathophysiology and
  • common after massive transfusion (40-57%)

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