Classic vs Delayed TRALI syndrome
Characteristics of the “classic TRALI syndrome” are:
- time of onset within 2 hours (usually up to 6 hours);
- rapid development;
- no other risk factors for ALI except transfusion;
- anti-neutrophil antibodies pathophysiology and
- onset after a single unit of blood product.
Characteristics of the “delayed TRALI syndrome” are:
- time of onset 6-72 hours after transfusion;
- slow development of clinical presentation;
- patients have other risk factors for ALI (i.e. sepsis, aspiration, near-drowning, disseminated intravascular coagulation, trauma, pneumonia, drug overdose, fracture, burns and cardiopulmonary bypass);
- two- step pathophysiology and
- common after massive transfusion (40-57%)
